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Potassium Bromide & Seizures

Undoubtedly, one of the scariest moments for a pet owner is witnessing their beloved four-legged friend experience a seizure. Seconds can feel like hours as you watch your dog convulse on the floor. You feel helpless and uncertain about what to do next. 

Once your dog stops convulsing and you take them to your veterinarian, your vet will likely recommend a conventional anticonvulsant medication. Dog owners should understand these medications, including their side effects, before administering them.

In this article, we'll cover everything you should know about potassium bromide for dogs (KBr). We'll discuss the risks, how the medication works, and alternatives that we recommend. Additionally, we will shed light on the wonders of holistic remedies that can greatly reduce your dog's seizure severity and frequency. Let's begin.

Dog Seizures: What Exactly Are They?

Before we dive into KBr for dogs, let's first discuss why it’s used: dog seizures. Up to 5% of all dogs experience seizures, making them the most commonly diagnosed neurological condition in dogs. Often referred to as 'fits' or convulsions, seizures are temporary and are caused by abnormal electrical activity in the brain.  

Seizures symptoms include:

  • Jerking
  • Drooling
  • Twitching
  • Stiffening
  • Chomping
  • Collapsing
  • Tongue chewing
  • Paddling of the legs
  • Foaming of the mouth
  • Involuntary urination or defecation

    dog seizure

    As you can imagine, witnessing a dog’s seizure can be terrifying for a dog owner.

    What Causes Seizures in Dogs

    Seizures in dogs have many causes. Identifying a seizure’s underlying cause is key to diagnosing the condition because some medications should not be given to dogs with certain health conditions, like liver disease.

    In other cases, the underlying cause of seizures is unknown. Many of these cases are diagnosed as canine idiopathic epilepsy. Epilepsy is at least two unprovoked seizures.  

    What is Canine Idiopathic Epilepsy

    Canine idiopathic epilepsy, an inherited disorder, is the most common type of seizures in dogs. Veterinarians often prescribe KBr for dogs with canine idiopathic epilepsy.

    Health Conditions that Cause Seizures

    The following ailments are often associated with seizures:

      dog seizure brain

      Toxins

      Toxins can also cause seizures in dogs. Tell your veterinarian if you suspect your dog has consumed any toxins. As part of the treatment plan for seizures, you vet will need to clear the toxin from your dog's body.

      Genetic Predisposition

      Certain dog breeds, listed below, are genetically predisposed to seizures and epilepsy:

      • Vizsla
      • Beagle
      • Keeshond
      • Golden Retriever
      • Labrador Retriever
      • Belgian Tervuren
      • Shetland Sheepdog

      If your dog is one of these breeds, learn all you can about seizures and epilepsy. For more information about seizures in dogs and how you can help your four-legged friend, click here.

      What is Potassium Bromide

      Now, let's get back to our main topic: KBr for dogs. KBr is a prescription anticonvulsant drug that controls seizure activity. It is often combined with a medication called phenobarbital, which also controls seizures. Veterinarians may prescribe KBr on its own for dogs who are resistant to phenobarbital or had a bad reaction to it.

      potassium bromide for dogs seizures

      What is Phenobarbital for Dogs

      Phenobarbital for dogs is a commonly prescribed anticonvulsant that controls seizure frequency and severity. It can either be used on its own or combined with KBr. Phenobarbital has many side effects. Therefore, KBr is often prescribed to either substitute for phenobarbital or lessen phenobarbital’s necessary dosage.

      How Does Potassium Bromide Work

      KBr works by decreasing and controlling seizure activity in the central nervous system. However, it can take three to four months for KBr to start working. In some cases, unfortunately, KBr may not work at all.

      Veterinarians may prescribe what is called a 'loading dose' to jump-start the medication's effects. A loading dose is a heightened dosage of the drug; after receiving a loading dose, a dog must be closely monitored for adverse effects. A loading dose of KBr, though, may not be enough to control a dog’s seizures. 

      Dangers of Potassium Bromide

      Like other conventional medications, KBr has a fair share of potential adverse reactions. Before administering the drug, a pet owner must understand the risks involved and recognize how the medication may affect their dog. A pet owner may decide that the potential adverse reactions aren’t worth the potential benefit for seizure control.

      Sedation

      Sedation, which brings about drowsiness and lethargy, is a common side effect of KBr and can be quite extreme. Although sedation doesn’t seem all that serious, remember that anticonvulsant medications like KBr and phenobarbital are intended to be daily, lifelong medications.

      For some dogs, the sedation eventually wears off. For others, it doesn't. Therefore, constant lethargy, day in and day out, may be your dog's "new normal." For many pet owners, this drastic change in their dog's personality is unsettling.

      Increased Hunger & Thirst

      Increased hunger and thirst are also common KBr side effects. Again, these may not seem all that bad, but excessive hunger can quickly lead to weight issues and additional health concerns.

      Increased Urination

      Increased thirst logically leads to increased water drinking and urination, which is particularly common for dogs who are taking KBr with phenobarbital. Increased urination isn't necessarily life-threatening, but it can greatly alter a pet owner’s day-to-day life because their dog will require more bathroom breaks.

      Loss of Coordination & Weakness of Hind Legs

      KBr can cause a loss of coordination (ataxia) and hindlimb weakness. In severe cases, KBr can cause hindlimb paralysis. Predicting these side effects is difficult and sometimes impossible. Knowing that KBr may cause paralysis is a hard pill to swallow.

      potassium bromide side effects

      Behavioral Changes

      KBr may cause behavioral changes like irritability and depression; these behavioral changes may not wear off over time. Again, KBr is a lifelong commitment. A pet owner may not want to deal with negative behavioral changes for the rest of their dog’s life. 

      Gastrointestinal (GI) Issues

      Many dogs and cats experience GI issues, listed below, when taking KBr:

      • Nausea
      • Constipation
      • Abdominal pain
      • Vomiting ± blood
      • Diarrhea ± blood

      These issues, as they worsen, can cause loss of appetite. In some cases, KBr’s GI side effects can be severe enough that a veterinarian will replace KBr with sodium bromide (NaBr) to control a dog’s seizures. 

      NaBr is typically less harsh on the stomach but it has its own share of potential adverse reactions. No conventional medication is entirely free from negative side effects.

      Dermatological Effects

      In some dogs, KBr may cause skin rashes and irritations.

      Bromide Toxicity

      Bromide toxicity can occur, even when dog owners administer KBr appropriately. Clinical signs of toxicity include the previously described side effects, only much more severe. If you think your dog has bromide toxicity, notify your vet immediately.

      Some dogs, including those with kidney or liver damage, have a higher risk for bromide toxicity. Before starting your dog on KBr, tell your vet if your dog has kidney or liver disease.

      Risks of Anticonvulsant Medications

      The list of KBr’s possible adverse reactions leaves many pet owners hoping for another option. Although other conventional anticonvulsant medications for dogs are available, none come without unsettling negative effects. Let's take a look at a couple of other anticonvulsant options.

      Phenobarbital Side Effects & Warnings

      As we previously mentioned, veterinarians commonly prescribe the anticonvulsant phenobarbital, often alongside KBr. However, phenobarbital’s negative side effects can be worse than KBr’s. Furthermore, dogs with conditions like Addison's disease (deficient cortisol production by the adrenal glands), kidney disease, liver disease, and respiratory problems should not take phenobarbital because it can worsen these conditions.

      Even dogs in good health can experience serious health problems, including anemia and liver damage, from long-term phenobarbital use. Liver damage often involves scarring of the liver tissue and consequent liver failure.

      Levetiracetam for Dogs

      Many dog owners prefer levetiracetam (Keppra) because it decreases the need for harsh medications like phenobarbital and KBr. However, levetiracetam has some drawbacks.

      First, levetiracetam typically has to be administered three times daily, which is probably inconvenient for many pet owners. Second, it causes side effects such as lethargy, behavioral changes, and GI issues.

      potassium bromide for dogs alternatives

      Zonisamide for Dogs

      Zonisamide has short- and long-term potential adverse reactions. Short-term effects include loss of coordination, loss of appetite, diarrhea, and vomiting. Its long-term effects include hyperthermia, skin reactions, and blood disorders.

      Phenobarbital & KBr & Their Lack of FDA Approval

      In people and animals, KBr has been used to treat seizures for over a century. Phenobarbital has also been used for years to manage seizure activity. However, neither drug is FDA approved for seizure treatment in people or animals. This is troubling for multiple reasons.

      First, this lack of FDA approval means that no drug company has provided conclusive evidence to the FDA that these drugs are safe and effective for seizure treatment. 

      Second, no FDA approval indicates that the drug companies haven't been able to provide evidence that manufacturing of either drug can consistently meet accepted quality control standards. 

      Finally, without FDA approval, pet owners may not fully know the risks of KBr and phenobarbital until it's too late.

      An All-Natural Alternative for KBr

      The potential adverse side effects of KBr are troubling, but pet owners should know about them. Only after pet owners have a full understanding of what’s at stake can they make an educated decision for their dog's health well-being.

      Now that you know about the effects of KBr and other conventional anticonvulsants, you may feel that you cannot administer the drug to your dog in good conscience... and we don't blame you! Luckily, there is an alternative—CBD for dogs—that is effective and remarkably safe. 

      In dogs, CBD has many benefits, including supporting and maintaining a normal inflammatory response and reducing anxiety.

      cbd oil for dogs

      Additional Seizure Treatment

      In addition to CBD oil, food therapy and acupuncture are alternative seizure control options.

      Food TherapyKetogenic Diet

      Your dog's diet is far more important than you may realize. In fact, your dog's food has a significant impact on their overall health and can be key to seizure treatment. A 2015 study in dogs with chronic idiopathic epilepsy reported that the dogs who ate a ketogenic diet had significantly fewer seizures than the dogs who ate a standard diet. Ketogenic diets are low in carbohydrates and high in fats. 

      Acupuncture

      Acupuncture can help dogs with seizures. You may not be on board with acupuncture for your dog, but it's comforting to know that there are alternative seizure treatment options that have positive results for dogs.

      How to Prevent Seizures in Dogs

      Finally, we want to briefly cover how pet owners can prevent seizures. Of course, not all seizures, like canine idiopathic epilepsy, are preventable. However, other seizure causes can and should be avoided.

      If your dog is experiencing seizures due to toxicity, remove the toxin from your home and your dog's environment. Toxic culprits include:

      • Batteries
      • Golf balls
      • Linoleum
      • Lead-infused paint
      • Foil attached to bottle tops
      • Plumbing or building materials

      Sometimes, stress and environmental changes can trigger seizures in dogs. If you can identify your dog’s seizure trigger (your veterinarian can help you with this), you can prevent a seizure by reducing your dog’s exposure to that trigger.

      KBr: A Final Thought

      At the end of the day, we understand how troubling seizures in dogs can be. Not knowing when the next episode may happen can be incredibly stressful for any pet owner and leave many considering whether conventional anticonvulsant medications may be a smart move. 

      Many dogs and cats benefit greatly from conventional anticonvulsant medications and have a better quality of life because their seizures are under control. Also, veterinarians closely monitor the health of dogs on these medications to watch out for possible liver and kidney problems. However, these medications can cause more harm than good in some dogs. Therefore, it’s worth considering all-natural alternatives like CBD oil.

      Furthermore, removing seizure-causing toxins and seizure triggers can help prevent seizures. Canine seizure disorders don't have to be the end of your dog's happy, active life.

      Sources

      https://www.wedgewoodpetrx.com/learning-center/medication-information-for-pet-and-horse-owners/potassium-bromide-for-dogs.html

      https://www.honestpaws.com/blogs/pet-care/dog-seizures-a-guide-to-helping-your-pup

      https://www.honestpaws.com/blogs/medication/levetiracetam-for-dogs

      https://www.fda.gov/animalveterinary/resourcesforyou/ucm301671.htm

      https://vet.osu.edu/vmc/companion/our-services/neurology-and.../more-epilepsy

      https://pets.webmd.com/dogs/dog-seizure-disorders#1

      http://www.canine-epilepsy-guardian-angels.com/potassium_bromide.htm

      https://www.hopkinsmedicine.org/neurology_neurosurgery/centers_clinics/epilepsy/conditions.html

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635653/

      https://www.vets-now.com/pet-care-advice/seizures-in-dogs/

      JoAnna Pendergrass, DVM

      JoAnna Pendergrass, DVM is a veterinarian and freelance medical writer in Atlanta, GA. After earning her Doctor of Veterinary Medicine degree from the Virginia-Maryland College of Veterinary Medicine, she pursued a non-traditional career path as a veterinarian. 

      JoAnna completed a 2-year postdoctoral research fellowship in neuroscience at Emory University’s Yerkes National Primate Research Center, then became a medical writer. As founder and owner of JPen Communications, a medical communications company, JoAnna is passionate about educating pet parents about pet care and responsible pet ownership. 

      Although she does not currently have any pets to call her own, she loves living vicariously through other pet parents and watching Nat Geo!

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