According to studies, osteoarthritis (OA) affects a staggering percentage of over 80% of dogs older than 8. Another devastating research statistic shows that its prevalence can reach up to 20% in dogs as young as 1 year old.

No dog owner wants to know that their dog is suffering; however, it can be difficult to find a solution when the market is flooded with information and quick fixes, some more popular and more efficient than others. One recent and incredibly popular source of hype is CBD oil.

But is it really worth the hype, or is there actual science to back up its popularity? In simple words, does CBD oil for dogs with arthritis actually work? Through our research, we have found that the answer is yes - CBD does help dogs with arthritis.

We're going to explain what the studies have discovered about the effects of CBD on dogs with arthritis so you can make the best choice for your companion. We will also provide dosing information and tips for choosing the best CBD for your dog's achy joints.

Can CBD Help Dogs With Arthritis? What the Research Actually Says

In a 2018 Cornell study, researchers found that giving arthritic dogs CBD at 2 mg/kg twice daily significantly reduced pain and improved mobility. The owners said their dogs moved more effortlessly, appeared less stiff, and were more active day-to-day. The study included 22 dogs and used owner CBPI & Hudson scores for objective pain/mobility evaluation. During the study, no side effects were reported. However, the ALP levels rose in some dogs.

There was also a 2025 double-blind study that randomly assigned 17 dogs with OA to receive either full-spectrum cannabis extract or a placebo for 90 days. The study found "a reduction of 2.4 points in Helsinki Chronic Pain Index (HCPI) scores compared to the placebo."

On the other hand, in 2021, a 23-dog double-blind crossover trial, published in the Journal of the American Animal Hospital Association, found no difference between the CBD and placebo groups on objective gait analysis, accelerometry, or owner questionnaires. Meanwhile, 14 of the 23 studied dogs had elevated liver enzymes.

In 2023, a systematic review and meta-analysis of 5 studies and 117 dogs concluded that CBD is considered safe for canine osteoarthritis and may reduce pain scores. Still, the certainty of efficacy evidence is very low. The authors explain that this is because the sample sizes are small, the studies are relatively short, and the methods used are different.

The main takeaway is that research on the use of CBD for dogs with arthritis, or any other condition, is new and ongoing. Studies are still limited, but based on current results, it is safe to assume that:

• CBD can help manage joint discomfort
• CBD has a favorable safety profile when used correctly

The efficacy of CBD for dogs with arthritis is promising but not proven. Therefore, veterinarians lack the necessary perspective to consider and recommend CBD as an established treatment.

CBD alone is not a miracle cure for arthritis in dogs. However, when used as an addition to an otherwise complete and individually tailored treatment plan, it can be useful.

How CBD Works for Joint Discomfort

CBD helps relieve joint discomfort by interacting with the dog's endocannabinoid system (ECS) to reduce inflammation and modulate pain signals.

The endocannabinoid system is a cell-signaling network that helps keep the dog's internal environment balanced (a state known as homeostasis) by regulating functions such as sleep, mood, pain, and appetite. Its three components are endocannabinoids, receptors (CB1 and CB2), and enzymes.

When a body function is out of balance, the body produces endocannabinoids, which bind to receptors and signal cells to restore homeostasis. Once the cells know what to do, the enzymes dissolve the bound endocannabinoid-receptor complexes.

Plant CBD works by mimicking the body's natural endocannabinoids and interacting with the endocannabinoid receptors.

As mentioned above, specifically for arthritis, CBD's effect on the dog's ECS has two results: reduced inflammation and blocked pain signaling.

A study using mouse models found that CBD can reduce the production of proinflammatory cytokines IL-6 and TNF-α (molecules that support inflammation), while elevating the levels of the anti-inflammatory IL-10 (molecules that stop inflammation).

As for its effect on pain control, studies explain that CBD can bind to the transient receptor potential vanilloid 1 (TRPV1) receptors, which play a key role in pain signaling. Once CBD binds to TRPV1 receptors, it makes them less sensitive to incoming pain stimuli.

CBD Dosage for Dogs With Arthritis

The recommended CBD dose for dogs with arthritis is 1-2 mg per kilogram of body weight (0.5-0.9 mg per pound) every 12 hours, according to the Cornell protocol.

For example, a 10-pound Miniature Dachshund with arthritis needs between 5 and 9 mg of CBD, twice a day. An arthritic 70-pound Labrador Retriever needs a much higher dose of 35-63 mg every 12 hours.

Splitting the total daily CBD dose into two doses helps keep the dog's blood CBD levels steady, ensuring ongoing support throughout the day. Plus, a smaller dose is easier to digest and will be gentler on the dog's tummy.

When introducing CBD oil or treats, it is important to start slowly - with a smaller dose and mixed with the dog's food. Mixing CBD oil with food results in slower absorption and delayed efficacy, but, once again, it is easier on the dog's stomach.

Then, you can gradually increase the CBD dose. Once the dog gets used to the supplement, you can squirt the oil directly into the dog's mouth, preferably sublingually (beneath the dog's tongue). This administration method yields the fastest efficacy.

Before starting your dog on CBD products, consult your trusted vet. Getting the vet's approval is vital, particularly if the dog is receiving other medications for the arthritis issue or coexisting conditions.

If your vet approves the use of CBD, discuss the best product for your dog's needs. Oils and edibles, such as treats and chews, are the most popular options. Injectable pet CBD products and CBD-infused skin patches exist, but their use remains limited.

Safety, Side Effects & Drug Interactions

In 2022 Bradley et al. found that a daily dose of 4 mg/kg/day of CBD is well tolerated in healthy dogs. One year later, a Frontiers study confirmed that "CBD is considered safe for treating canine OA."

A recent 2025 paper agrees, stating "that CBD administration to dogs is generally safe and well tolerated for short-term use."

However, as with any supplement, side effects are possible. Drowsiness and GI upset (vomiting or diarrhea) are the most frequently reported adverse events. The good news is that they are rare, transient, and can be managed by adjusting the CBD dose.

"The few mild side effects observed resolved spontaneously within 24 hours," in a 2025 study published by Frontiers in Pharmacology.

Plus, you can reduce the risk of GI upset and drowsiness by introducing CBD gradually and starting with a low dose.

Elevated liver enzymes are a more concerning side effect. A Cornell trial reports that "serum alkaline phosphatase (ALP) rose significantly during CBD treatment." Similarly, a 23-dog double-blind crossover trial reported elevated liver enzymes after CBD use in 14 of the studied dogs.

Complex mechanisms regulate ALP levels and depend on many variables, including stress, age, and certain medications (such as corticosteroids, which are frequently used in arthritic dogs). Plus, the increased ALP levels in dogs supplemented with CBD were not accompanied by elevated alanine transaminase (ALT) levels (another liver enzyme). To diagnose liver damage, both ALP and ALT need to be elevated.

The exact role of CBD in liver enzyme alterations is unclear. However, to be on the safe side, a vet will recommend scheduled blood tests for liver enzymes. Such checkups are critical, especially if the dog is also taking NSAIDs (non-steroidal anti-inflammatory drugs), because the same hepatic pathways that metabolize CBD also metabolize them.

Keep in mind that the "FDA has not approved cannabis for any use in animals, and the agency cannot ensure the safety or effectiveness of these products."

Therefore, when choosing a CBD product, it is important to look for the Certificate of Analysis (COA) as proof that an independent laboratory has tested it.

It is also imperative that you buy CBDs made exclusively for dogs. Human CBDs contain THC (tetrahydrocannabinol), a type of cannabinoid found in marijuana, which is toxic to dogs. Pet CBD products are sourced from hemp and contain safe levels of less than 0.3% THC.

How to Choose a CBD Oil for an Arthritic Dog (Best CBD for Dog Arthritis)

The modern pet CBD market is saturated, and unfortunately, not all brands are transparent. In fact, studies show that over 56% of pet CBD product labels are inaccurate, either lacking the advertised CBD potency or misrepresenting the THC content. The mislabeling poses direct risks of underdosing (lack of efficacy) or even life-threatening overdosing for dogs.

Therefore, when choosing a CBD oil for an arthritic dog, as a pet owner, you need to be extra careful and pay attention to several criteria. Let's explain what you need to check before making a CBD purchase.

• Exclusive Pet Formulation. First, make sure you are looking at CBD products made exclusively for pets. As mentioned, human CBD is sourced from marijuana and has THC, while pet products must be extracted from hemp. Honest Paws uses hemp, and its products are THC-free.
• Full-Spectrum Formulation. Check the extract type. CBD oils come as full-spectrum, broad-spectrum, and isolate formulas. The full-spectrum option is used in the research cited in this article and is considered the best. It contains different cannabinoids and active ingredients with entourage effects. The Honest Paws Mobility line is crafted with high-quality and full-spectrum CBD oil.
• USDA Organic Certification. Ideally, choose products made with organic ingredients. Honest Paws uses USDA-certified organic hemp grown in the USA, free of GMOs and pesticides.
• Certificate of Analysis (COA). A COA is an official document issued by an independent laboratory. It confirms that a third party has tested the CBD product for potency, ingredients, and safety. A reputable pet CBD brand, such as Honest Paws, displays COAs for each batch of its products.
• Clear mg-per-mL Labeling. Always choose pet CBD products that are clearly labeled and offer straightforward dosing instructions. The amount of CBD per mL of oil or piece of edible is clearly displayed on Honest Paws products. The brand's dosing instructions are also easy to read and follow.

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Beyond CBD: A Complete Joint-Care Plan

A complete joint care plan goes beyond CBD products and includes several aspects. Here is a more comprehensive explanation.

• Weight Management. Excess body weight is a major risk factor for OA in dogs. Studies suggest that losing as little as 6.10% of body weight noticeably reduces lameness, while a loss of 8.85% results in clear gait improvement in arthritic dogs.
• Controlled Exercise. Practice short, slow walks (10 to 15 minutes) several times a day. Avoid high-impact activities, such as jumping, running, or ball-chasing, as they put extra pressure on the joints.
• Joint Nutraceuticals. Use joint health supplements such as green-lipped mussels (GLM), omega-3s, glucosamine, and chondroitin. Supplementing arthritic dogs with a mix of CBD and omega-rich krill oil results in reduced pain and inflammation, according to studies.
• Home Modifications. Modify the home to make it more joint-friendly. For example, install stairs or ramps to access elevated surfaces, place non-slip rugs on slippery floors, block stairs with puppy gates, and invest in orthopedic dog beds. You can also use dog lift harnesses to assist your dog when getting up or using the stairs.
• Physical Therapy. Many forms of physical therapy are helpful for dogs with OA, from old-fashioned swimming to newer alternative therapies such as acupuncture, electrical stimulation, shockwave therapy, and laser therapy.
• Prescribed Medications. Last but not least, dogs with arthritis need prescription meds for pain and inflammation relief. Non-steroidal anti-inflammatory drugs (NSAIDs) are the medication of choice. However, this is a topic that requires elaborate consultation with your veterinarian.

Conclusion — Is CBD Worth Trying for Your Dog's Arthritis?

Yes, CBD is worth trying for your dog's arthritis. Despite the real limitations and lack of long-term efficacy proof, the current trial data and results are encouraging.

CBD helps reduce pain and inflammation in arthritic dogs, resulting in improved overall mobility and mood. Plus, if used correctly, it is perfectly safe for dogs of all ages.

By correct use, we refer to three key components. First, purchase a high-quality CBD product formulated exclusively for dogs. Second, supplement the dog's diet with CBD after obtaining the vet's approval and under veterinary monitoring. Third, use the CBD oil as a treatment addition rather than a standalone miracle cure.

Bottom line: if your dog has OA, schedule a vet visit and ask about CBD. Develop a strategy with your trusted veterinarian and follow their instructions.